20 Nov 08 November ushers in American Diabetes Month

November ushers in American Diabetes Month – not only a time to be thankful for bustling basic and clinical research underway on the disease, but also the unofficial start of the holiday season. Between now and New Year’s, people with diabetes must navigate a tempting course of sugar-centric festivities, maintaining a delicate nutritional balance against all odds.

“It’s possible,” said Nicholas Jospe, M.D., chief of Pediatric Endocrinology at the University of Rochester Medical Center’s (URMC) Golisano Children’s Hospital. “This is the time of year where we’re assaulted by sugar, but with careful attention, people with diabetes can uphold good habits.”

Nearly eight percent of the population – or 23.6 million adults and children – have diabetes, a metabolic disease in which the body struggles to move simple sugars from the blood stream to feed cells. Since these people either make little or no insulin (type 1), or have become resistant to their own insulin (type 2), the hormone that assists this sugar transfer, they must take it in the form of daily injections and vigilantly monitor blood-sugar levels. When these numbers drop, diabetes patients feel dizzy, start shaking, and even experience confusion; on the other extreme, maintaining elevated levels ups their risk for severe complications like cardiovascular disease, nerve damage, kidney disease and blindness.

Having seen Rochester’s rate of annual type 1 diagnoses more than triple in the past two decades (climbing from 25 to 80 new cases each year), Jospe dedicates time to clinical research. Locally, he partners with URMC’s Autoimmunity Center of Excellence (ACE), one of nine national centers funded by the National Institute of Allergy and Infectious Disease to conduct basic research on autoimmune diseases like lupus, multiple sclerosis, and type 1 diabetes (in this type, the body produces antibodies which indicate ongoing destruction of its own insulin-producing cells). He also participates as an investigator for TrialNet, an international, National Institutes of Health-funded project working to prevent, delay, and even reverse the progression of this type of diabetes.

Tags: Diabetes Month

07 Oct 08 Glucomannan Group Had a More Significant Weight Loss According to Study

Glucomannan Side Effects - [Chronic use of glucomannan in the dietary treatment of severe obesity]

Vita PM, Restelli A, Caspani P, Klinger R.

Centro per la Farmacoterapia delle Malattie Nutrizionali, Università degli Studi di Milano.

Two groups of 25 severely obese patients underwent 3 months of hypocaloric diet therapy either alone or associated with a glucomannan-based fibrous diet supplement (approx. 4 g/die in 3 doses). The comparative analysis of the results obtained in both groups showed that the diet + glucomannan group had a more significant weight loss in relation to the fatty mass alone, an overall improvement in lipid status and carbohydrate tolerance, and a greater adherence to the diet in the absence of any relevant side effects. Due to the marked ability to satiate patients and the positive metabolic effects, glucomannan diet supplements have been found to be particularly efficacious and well tolerated even in the long-term treatment of severe obesity.

PMID: 1313163 [PubMed - indexed for MEDLINE]

Tags: Glucomannan, severe obesity, side effects of Glucomannan

07 Oct 08 Obesity and Glucomannan

Obesity

Clinical evidence suggests glucomannan may be beneficial in weight loss (PMID 16320857).

Glucomannan and obesity: a critical review.
Keithley J, Swanson B.

Rush University College of Nursing, Chicago, Ill, USA.

Glucomannan (GM) is a soluble, fermentable, and highly viscous dietary fiber derived from the root of the elephant yam or konjac plant, which is native to Asia. Preliminary evidence suggests that GM may promote weight loss. This review summarizes studies using GM for weight loss as well as studies investigating its mechanisms of action. At doses of 2-4 g per day, GM was well-tolerated and resulted in significant weight loss in overweight and obese individuals. There is some evidence that GM exerts its beneficial effects by promoting satiety and fecal energy loss. Additionally, GM has been shown to improve lipid and lipoprotein parameters and glycemic status. Further investigation of safety, efficacy, and mechanisms of action is needed to determine whether GM can help to decrease the high prevalence of overweight and obesity in the United States.

FibraSlim has Glucomannan for just $7.99 delivered.

28 Aug 08 Glucomannan for Blood Sugar, Weight Loss, Lower Cholesterol

Glucomannan

FibraSlim contains glucomannan which is a water-soluble dietary fiber that is derived from konjac root, but why for weight loss? . Like other forms of dietary fiber, glucomannan is considered a “bulk-forming laxative.” Glucomannan promotes a larger, bulkier stool that passes through the colon more easily and requires less pressure—and subsequently less straining—to expel.

How much glucomannan should I take?

FibraSlim for weight loss, 1 to 3 grams before each meal has been effective. When using glucomannan and other dietary fiber supplements, it is best to start out with a small amount and increase gradually. It is recommended to drink at least 8 ounces of water each time any bulk-forming laxative, including glucomannan, is taken.

FibraSlim for Constipation

Tags: blood sugar, constipation, weight loss

12 Jun 08 Glucomannan Good, Lipozene Bad (and a Scam, too!)

Fiber in general and Glucomannan in particular, are very good for weight loss. But not 2 pounds per week. That isn’t even healthy. Glucomannan has been used to treat diabetes, hypoglycemia, high blood pressure, high cholesterol, constipation and weight loss (moderate), so, what is it? When you’re trying to trim down, soluble fiber is your BFF — it expands in your digestive tract, making you feel fuller and warding off snack attacks. But a girl can down only so many bowls of All-Bran before she feels so gassy and bloated she’s afraid to leave the bathroom. There is one kind of soluble fiber, however, that works without the nasty side effects. Glucomannan, which comes from an Asian plant known as the konjac, or elephant yam, is nature’s get-skinny sponge. Able to expand up to 50 times its own water weight, it’s one of the world’s most effective fibers, so you can cut down on calories without even trying. Researchers at Chicago Rush University College of Nursing reviewed 12 clinical trials to determine the benefits of glucomannan and found that it promotes weight loss and satiety.

Glucomannan is also flavorless, so you can add it in powder form to just about anything, from smoothies to frozen entrées to sauces. Mix it in thoroughly (otherwise you might get unappetizing clumps that can stick in your throat) and wait 2 to 3 minutes for it to soak up whatever sauce, broth, dressing, or other liquid is on your plate. It will thicken your food and fill up your stomach, sending satiety signals to your brain. Because of that, you’ll want to wash it down with plenty of water, so drink at least 8 ounces of H2O with every meal or snack. A good brand is FibraSlim - This month is on sale two bottles - 360 caps for just $29.99 with shipping. The same amount of Lipozene would be at least $90!

Lipozene is brought to you by the same marvelous company that had to pay fines to the FTC for making bad claims about Propolene.

Tags: fiber, FibraSlim, Glucomannan, Lipozene, soluble fiber, weight loss

07 Jun 08 Constipation

The popular painkiller codeine can be ineffective or, worse, cause serious reactions if you are among those people whose bodies do not process the medication properly.

The liver converts codeine into morphine using the enzyme CYP2D6, a process that causes pain relief in most people. However, genetic differences in some people cause either too much or too little of the enzyme to be produced, resulting in less than pleasant results, reports Public Citizen, a national, nonprofit consumer advocacy group, in its June Worst Pills, Best Pills newsletter.

People whose liver’s produce higher than normal CYP2D6 levels convert more of the codeine into morphine — a situation that could cause excessive sedation, severe constipation and other side effects. While this only occurs in about 4 percent of Caucasian North Americans, prevalence is much higher in people from Greece and Portugal (10 percent), Saudi Arabia (20 percent) and Ethiopia (30 percent).

Tags: constipation

06 Jun 08 Parents are Big Part of Problem, Block Teen Weight Loss

Kids really need a drill sargent. The drill sargent really lives the troops he drills all day. Parents want to be best friends with their children and so when it comes to weight loss, parents talk about it but provide almost no meaningful support. This is the conclusion tof research published in this weeks Journal of Pediatrics.

The parents who correctly recognized that their teen need to lose weight would talk a good game about dieting but did not prepare good meals and keep nutritious snack around the house. Instead they would bring salty snack and colas for the teen to eat.

Glucomannan is a safe diet pill for teens:

Although the exact mechanism of how fibers promote weight loss has not been determined, a number of hypothetical theories have been put forward by scientists.

1. Dilution of Energy Density: It is known that fibers have a low caloric value as compared to other food sources [2]. For this reason, adding it to the food creates a lowering of the energy-to-weight ratio of food, thereby reducing the amount of calories that are taken in.
2. Promotion of Satiety: A number of studies have shown that dietary fibers like glucomannan promote satisfaction in the human food consumption. Many different hypotheses as to how fibers do this both psychologically, physically and chemically have been shown. [2, 3, 4, 5]
3. Fecal Energy Loss: Studies have shown that soluble fibers act in the gastrointestinal tract and have been known to reduce the absorption of proteins and fats [6]. It has been further proposed that dietary fibers do this by reducing the contact of these substances to the walls of the intestine, and therefore prevent their absorption. There is considerable evidence to show that glucose and carbohydrate uptake is also reduced because of this action, thus it also shows its hypoglycemic effects [7]. Although these are just propositions, the exact mechanism of this still remains unclear [2].

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Tags: Glucomannan, teens, weight loss

06 Jun 08 Glucomannan for Weight Loss

Glucomannan (use to treat diabetes, hypoglycemia, high blood pressure, high cholesterol, constipation and weight loss)

What is it? Glucomannan is a dietary supplement used for diabetes, hypoglycemia (low blood sugar), high blood pressure, high cholesterol (blood fats), constipation (difficulty having a bowel movement), and weight loss.

Other names for Glucomannan include: Glucomanna, Konjac, Konjac Fiber, Konjac Glucomanna, Konjac Glucomannan, and Manna.

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Tags: Add new tag, cholesterol, Glucomannan, konjac, weight loss

06 Jun 08 Glucomannan

Glucomannan

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07 May 08 You May Need to Lose Weight, But Osteoporosis is Still Important

Androgen Deprivation Therapy Causes Bone Loss

When successful, the combination of the two therapies keep the tumor from growing. Unfortunately, patients who get the androgen deprivation therapy lose from 4 to 13% of their bone density annually, when compared to healthy men who will lose on average from .5 to 1% per year. Usually, it is post menopausal women who are considered to be at the greatest risk for bone density loss, but in reality, men have the greater rate.

The original study’s purpose was to document the effects of exercise on other quality-of-life measures, including:

• fatigue
• ability to sleep
• nausea
• cardiac fitness

The dual energy x-ray, known as DEXA scans, collected during those analyses showed such dramatic and compelling results that the research team went back to develop the bone loss portion of the study.

Tags: bone density